Japanese encephalitis (JE) is a preventable cause of mosquito-borne encephalitis. Encephalitis is a state of inflammation of the brain parenchyma, commonly resulting from either an infectious cause or when the body's immune system gets activated inappropriately against the neural antigens. Most human infections of the JE virus are asymptomatic or result in only mild symptoms. Psychiatric symptoms, in conjunction with neurological features, may be seen in the acute phase and more commonly during the convalescent period. A case of JE has been reported here in which the patient presented with irrelevant talk, suspiciousness, and verbally and physically abusive behavior, with a history of fever eleven days before presentation. He was started on tab. quetiapine 50 mg and levetiracetam 1 gm, and there was near complete remission after 10 days. The uniqueness of this case is the presence of psychotic symptoms with intact sensorium and cognition, and there was no amnesia.
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