Eastern Journal of Psychiatry

Register      Login

VOLUME 16 , ISSUE 1-2 ( February-August, 2013 ) > List of Articles

Original Article

Comparison of Aripiprazole Versus Haloperidol for the Treatment of Childhood and Adolescent Non-Affective Psychotic Disorders

Monideepa Banerjee, Vinod K. Sinha

Keywords : aripiprazole, haloperidol, childhood, psychosis

Citation Information : Banerjee M, Sinha VK. Comparison of Aripiprazole Versus Haloperidol for the Treatment of Childhood and Adolescent Non-Affective Psychotic Disorders. 2013; 16 (1-2):77-82.

DOI: 10.5005/EJP-16-1--2-77

License: CC BY-NC 4.0

Published Online: 13-10-2021

Copyright Statement:  Copyright © 2013; The Author(s).


Background: Aripiprazole, a novel antipsychotic, is an effective and safe agent in psychotic disorders of adults but with limited evidence of use in pediatric patients. This study compares efficacy and safety of aripiprazole monotherapy with haloperidol for schizophrenia and related psychotic disorders in children and adolescents. Methods and Materials: Total 30 patients with ICD-10 DCR diagnosis of schizophrenia and acute psychotic disorders, were assigned to receive either aripiprazole (10-15 mg/day) or haloperidol (10-15mg/day) for four weeks, with each group containing 15 patients respectively. Primary outcome measure was Positive and Negative Syndrome Scale for Schizophrenia (PANSS) while secondary outcome measures were three PANSS subscales and Clinical Global Impressions-Severity of Illness (CGI-S). Assessments were done at baseline and then on weekly basis until endpoint. Extrapyramidal side effects and akathisia were rated weekly by Simpson-Angus Scale (SAS) and Barnes Akathisia Scale (BAS). Body weight and serum prolactin were measured and electrocardiogram recorded at baseline and at end point. Results: Endpoint improvement for the aripiprazole group was not significantly different from haloperidol group on PANSS total score, and PANSS positive and negative subscale scores. Haloperidol produced significantly greater improvement in PANSS general psychopathology subscale score and CGI-S score at endpoint. Aripiprazole produced significantly less extrapyramidal side effects and weight gain. Haloperidol produced significantly greater elevations in serum prolactin levels while QT(c) changes were nonsignificant in both groups. Conclusions: This trial shows that aripiprazole therapy was as efficacious as haloperidol in improving both positive and negative symptoms of psychotic disorders in children and adolescents but demonstrated better tolerability

PDF Share
  1. Volkmar, F.R. (1996). Childhood and adolescent psychosis: a review of past ten years. J Am Acad Child Adolesc Psychiatry 1996; 35 (7): 843-851.
  2. Gilberg C, Wahlstrom J, Forsman A, et al. Teenage psychosis-epidemiology, classification and reduced optimality in the pre-, peri- and neonatal periods. J Child Psychol Psychiatry 1986; 27: 87–98.
  3. Kumra S, Frazier JA, Jacobsen LK, et al. Childhood-onset schizophrenia: a double blind clozapine-haloperidol comparison. Arch Gen Psych 1996; 53: 1090-1097.
  4. Sikich L, Hamer, RM, Bashford, RA, et al. Apilot study of risperidone, olanzapine and haloperidol in psychotic youth: a double blind, randomized eight week trial. Neuropsychopharmacology 2004; 29:33-145.
  5. Findling, RL, Kusumakar V, Daneman D, et al. Prolactin levels during longterm risperidone treatment in children and adolescents. J Clin Psychiatry 2003; 64: 1362–1369.
  6. Ratzoni G, Gothelf D, Brand-Gothelf D, et al. Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study. J Am Acad Child Adolesc Psychiatry 2002; 41 (3): 337-343.
  7. Kane JM, Ingenito G, Ali M. Efficacy of aripiprazole in psychotic disorders: comparison with haloperidol and placebo. Schizophr Res 2000; 41: 39-46.
  8. Potkin, S.G., Saha, A., Kujawa M, et al. Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone versus placebo in patients with schizophrenia and schizoaffective disorder. Arch Gen Psych 2003; 60: 681-690.
  9. Findling RL, Blumer JL, Kauffman R, et al. Pharmacokinetic effects of aripiprazole in conduct disorder. Eur Neuropsychopharmacol 2005; 13: 34-40.
  10. Barzman DH, Delbello M, Kowatch R, et al. The effectiveness and tolerability of aripiprazole for pediatric bipolar disorder: a retrospective chart review. J Child Adolesc Psychopharmacol 2004; 14: 539-600.
  11. Marder SR, McQuade RD, Stock E, et al. Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term placebo controlled trials. Schizophr Res 2003; 61: 123-136.
  12. Keck PE, McElroy SL. Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic. Expert Opin Investig Drugs 2003; 12 (4): 655-662.
  13. Kay SR, Opler LA, Lindenmayer JP. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261-276.
  14. Guy W. ECDEU assessment manual for psychopharmacology 1976. Washington DC, U.S. Department of Health Education and Welfare.
  15. Simpson GM, Angus JWS. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand 1970; 212 (Suppl 44): 11-19.
  16. Barnes TRE. A rating scale for drug induced akathisia. British Journal of Psychiatry 1989; 154: 672-676.
  17. Barnas ME, Hussain N, Petrides G. Treatment emergent psychosis with aripiprazole. J Clin Psychiatry 2005; 66: 1339.
  18. Holzer K, Eap CB. Aripiprazole and suicidality. Int Clin Psychopharmacology 2006; 21: 125-126.
  19. McQuade R, Stock E, Marcus R, et al. Acomparison of weight change during treatment with olanzapine or aripiprazole: results from a randomized, double blind study. J Clin Psychiatry 2004; 65 (Suppl 18): 47-56.
  20. Spencer KS, Campbell M. Children with schizophrenia: diagnosis, phenomenology and pharmacotherapy. Schizophr Bull 1994; 20 (4): 713-725.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.