Eastern Journal of Psychiatry

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VOLUME 18 , ISSUE 1 ( January-June, 2015 ) > List of Articles


Kleine - Levine Syndrome (A Rare Case Report)

Priyajyoti Chakma, Punya Dhar Das, Bhubaneswar Roy, Prabhat Kumar Agrawal

Keywords : Hyper phagia, Kleine–Levin syndrome, hyper somnolence, Lithium

Citation Information : Chakma P, Das PD, Roy B, Agrawal PK. Kleine - Levine Syndrome (A Rare Case Report). 2015; 18 (1):48-50.

DOI: 10.5005/EJP-18-1-48

License: CC BY-NC 4.0

Published Online: 13-10-2021

Copyright Statement:  Copyright © 2015; The Author(s).


Kleine–Levin syndrome (KLS) also called sleeping beauty syndrome, is a rare sleep disorder with onset in early adolescence. Common symptoms are episodes of hyper somnolence, behavioral and cognitive disturbances (including specific feelings of derealization), hyperphagia and hypersexuality. The cause is not known and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after ruling out other psychiatric and neurological disorders. Our case, a 15 year old boy with duration of illness of 3 years, episodic presented with hypersomnia, increased appetite, irritability, hyper sexuality and behavior abnormality mainly fearfulness and suspiciousness. Patient responded well to lithium therapy. The priority of this report is to add the existing clinical knowledge of psychiatrists, neurologists and physicians.

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  1. Kleine. Levin syndrome: History and brief review. Eur Neurol 2008; 60: 212.4.
  2. Diagnostic and Coding Manual, International Classification of Sleep Disorders. 3rd ed. Westchester Illinois: American Academy of Sleep Medicine; 2013.
  3. Kleine. Levin syndrome: A systematic review of 186 cases in the literature. Brain 2005; 128: 2763.76.
  4. L. & Hirshkowitz, M. (2000) Sleep disorders. In: Kaplan & Sadock's Comprehensive Text Book of Psychiatry, Edn. 7th, (Eds.) Sadock, B.J. and Sadock, V.A., Philadelphia, Lippincott Williams and Wilkins
  5. Oxford: Oxford University Press.
  6. A. (1954) Syndromes of episodic hypersomnia, buiimia and abnormal mental states. JAMA, 154, 1081-1083.
  7. & Stores, G. (1994) Kleine-Levin syndrome: a cause of diagnostic confusion. Archieves of Disease in Childhood, 71, 355-357.
  8. G., Young. J.P.R. & Thomas. D.J. (1988) Kleine-Levin syndrome: report of two caseswith onset of symptoms precipitated by headtrauma. British Journal of Psychiatry, 152, 410-412.
  9. (1962) Periodic hypersomnia and megaphagia in adolescent males. Brain, 85, 627-656.
  10. A. (1998) Organic Psychiatry: The psychological consequences of cerebral disorder, Edn 3, Backwell Science Ltd., 732-733.
  11. Psychosis in a case of kleine. levin syndrome: A diagnostic challenge. Indian J Psychol Med 2014; 36: 192.4.
  12. Kleine. Levine syndrome in an adolescent female and response to modafinil. Ann Indian Acad Neurol 2011; 14: 50.2.
  13. Klein Levin syndrome - A case report. Indian J Priv Psychiatry 2012; 6: 52.4.
  14. Kleine. Levin syndrome with rapid cycling. case report and review of the literature. Neurology 2014; 82: 294.
  15. Kleine. Levin syndrome following acute viral encephalitis. Biol Psychiatry 1986; 21: 1301.4.
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