Eastern Journal of Psychiatry

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VOLUME 16 , ISSUE 1-2 ( February-August, 2013 ) > List of Articles


“Aripiprazole, A New Generation Antipsychotic: Current Research and Clinical Practice

Gurvinder Pal Singh, Neeraj Loona, Rajinder Kumar Singla

Citation Information : Singh GP, Loona N, Singla RK. “Aripiprazole, A New Generation Antipsychotic: Current Research and Clinical Practice. 2013; 16 (1-2):1-5.

DOI: 10.5005/EJP-16-1--2-1

License: CC BY-NC 4.0

Published Online: 13-10-2021

Copyright Statement:  Copyright © 2013; The Author(s).


Aripiprazole is the new generation class of antipsychotic. Chemically, aripiprazole is a quinolinone derivative. Aripiprazole gives its action through the partial agonist mechanism at dopamine D2 and 5- HT1A receptors, and is also an antagonist at 5-HT2A receptors. Preclinical and placebo controlled trials of aripiprazole have evaluated 2A that aripiprazole is effective in the treatment of schizophrenia. Comparative trials of aripiprazole with typical and atypical antipsychotics have shown that aripiprazole has similar efficacy as haloperidol and olanzapine. Data also suggest that aripiprazole is safe and its tolerability profile is good. This molecule is also showing promising results in the treatment of bipolar disorders but the evidence is still inadequate. This article critically examines the various clinical trials conducted in various countries regarding the therapeutic profile of aripiprazole.

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