A Comparative Study of Liver Function Test in a Group of Persons with Alcohol Dependence Disorder
Anumita Pushilal, Kamal Narayan Kalita
Citation Information :
Pushilal A, Kalita KN. A Comparative Study of Liver Function Test in a Group of Persons with Alcohol Dependence Disorder. 2009; 12 (1-2):21-27.
Alcohol related diseases affect 5-10% of the world's population each year. Medical illness is a common consequence of heavy drinking. Chronic and excessive alcohol ingestion is one of the major causes of liver diseases. Laboratory testing can assist the clinician in providing objective, non-judgmental feedback to alcoholic patients on negative physical consequences of excessive drinking. Laboratory testing can also assist the clinician in providing objective, non-judgmental feedback to alcoholic patients on negative physical consequences of excessive drinking. This purposive cross sectional study aims to compare the values of hepatic enzymes along with total protein in a group of chronic alcoholics and a matched controlled group. 25 individuals fulfilling ICD-10 criteria for alcohol dependence syndrome were recruited and were applied AUDIT. The values of the hepatic enzymes were significantly raised along with reversal of the albumin globulin ratio in majority of the cases. Multiple physical problems were also observed in the study group.
Baber F, Stephens RS, Marlatt GA (1987). Social drinking as a health and psychosocial risk factor: Anstie's limit revisited. In Recent Developments Of Alcoholism. Vol 5. Galanter M (ed). Plenum Press, New York, pp 373-402.
Marc A. Schuckit. Alcohol and Alcoholism. In Fauci SA, Kasper DL, Longo DL, Braunwald E, Hauser S, Jameson JL, Loscalzo J eds. Harrisons Principles Of Internal Medicine, 17th ed. Mc Graw Hills. 2007: 2562-2564.
Mailliard ME, Sorel MF. Alcoholic Liver Disease. In Fauci SA, Kasper DL, Longo DL, Braunwald E, Hauser S, Jameson JL, Loscalzo J eds. Harrisons Principles Of Internal Medicine, 16th ed. Mc Graw Hills. 2005: 1855-1856.
Florence Wong et al. Alcoholic Liver Disease: Medicine International (Indian ed) 1994. 469-471.
Sherlock S, Dooley J. Diseases of the Liver and Biliary System. 9th ed. Pg 373.
Maher JJ. Exploring alcohol's effect on liver function. Alcohol Health and Research World. 1997; 21: 5-12.
Situnayake RD, Crump BJ, Thurnham DI et al. Lipid peroxidation and hepatic antioxidants in alcoholic liver disease. Gut 1990; 31: 1311-1313.
Allen JP, Litten R. The role of laboratory tests in alcoholism treatment. J Substance Abuse Treatment. 2001; 20: 81-85.
Miller WR, Zweben A, Diclemente CE et al. Motivational Enhancement Theory Manual: A Clinical Research Guide For Therapist Treating Individuals with Alcohol Abuse and Dependence. 1999. Project MATCH Monograph series, vol. 2, Publication number 94-3723. National Institute on Alcohol Abuse and Alcoholism Rockville MD.‘
Saunders JB, Aasland OG, Babor TF et al. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addictions. 1993; 88: 791-804.
Bohn MJ, Babor TF, Kranzler HR. the alcohol use disorder test (AUDIT): validation of the screening instrument for use in medical settings. J Stud Alcohol. 1995; 56: 423-432.
WHO Collaborative Project on Unrecorded Consumption of Alcohol, Kamataka, India, 2007.
Bellantani S, Saccaccio G, Costa G et al. Drinking habits as co-factor of risk for alcohol induced liver damage. Gut 1997; 41: 845-50.
Benegal V. Dimensions of Substance Abuse Problems and the Need to Network. Deaddiction Quarterly. 1998; 2 and 3: 3-6.
Multimer DJ, Burra P, Neuberger JM et al. Managing Severe Alcoholic Hepatitis Complicated by Renal Failure. QJ Med. 1993; 86: 649-56.
Pinto HC, Baptista A, Camilo ME et al. Non Alcoholic steatohepatitis: Clinic opathological Comparison with Alcoholic Hepatitis in Ambulatory and Hospitalised Patients. Dig Dis Sci 1996; 41: 172-9.
Zhon SL, Gorden RE, Bradbury M et al. Ethanol upregulates fatty acid uptake and plasma membrane expression and export of aspartate aminotransferase in HepG2 cells. Hepatology 1998; 27: 1064-74.
Sorbi D, Boynton J, Lindor KD. The Ratio of Aspartate Aminotransferase to Alanine Aminotransferase: Potential Value in Differentiating Nonalcoholic Steatohepatitis from Alcoholic Liver Disease. The American J. of Gastroenterology. 1999; 94-4: 1018-1022.
Cohen et al. SGOT: SGPT ratio- an indicator of Alcoholic Liver Disease. Dig Dis Sci. 1979; 24: 835.
Ludwig S, Kaplowitz N. Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in rat. Gastroenterology 1980; 79: 545-9.
Dunn W, Angnlo P, Sandersons et al. Utility of a New Model to Diagnose an Alcohol Basis for Steatohepatitis. Gastroenterology 2006; 131: 1057-1063.
Huang Y, Chan C, Wui J, Pai C, et al. Serum level of interlukin-8 in alcoholic liver disease, relationship with disease stage, biochemical parameters and survival. Journal of Hepatology. 1996; 24: 377-84.
Pratt DS, Kaplan MM. Laboratory Tests. In: Schiff ER, Sorell MF, Maddrey WC, eds. Sciffs Diseases of the Liver, 8th ed. Vol. I. Philadelphia: Lippincott-Raven, 1999:205-44.
Pratt DS, Kaplan MM. Evaluation of abnormal liver enzyme results in asymptomatic patients. The New England J. of Medicine, 2000, 342:17:1266-71.
Goldberg, Martin JV, Role of Gamma Glutamyl Transpeptidase Activity in the Diagnosis of Hepatobiliary Disease. Digestion 1975;12:232-46.
Rosalki SB, Tarlaw D, Ran D. Plasma Gamma Glutamyl Transpeptidase elevation in Patients Receiving Enzyme Inducing Drugs, Lancet 1971;2:376-7.
Helander A. Biological Markers in Alcoholism. J Neural Transm Suppl, 2003;66:15-32.
Mancinelli R, Ceccanti M. Biomarkers in Alcohol Misuse: Their role in the Prevention and Detection of Thiamine Deficiency, Alcohol and Alcoholism 2009; 44-2: 177-182.
Lucey MR, Mathurin P, Morgan TR. Alcoholic Hepatitis. The New England J of Medicine, 2009;360:2758-69.
Forrest EH, Morris AJ, Stewart Set al. The Glasgow Alcoholic Hepatitis Score Identifies Patients Who May Benefit From Corticosteroids. Gut 2007;56: 1743-6.